High-Resolution Analysis of Zn Coordination in the Alkaline Phosphatase Superfamily by EXAFS and X-ray Crystallography
نویسندگان
چکیده
Department of Chemistry, Stanford University, Stanford, CA 94305, USA Department of Biochemistry, Stanford University, Stanford, CA 94305, USA Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305, USA Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA Stanford Synchrotron Radiation Lightsource, SLAC, Stanford University, Menlo Park, CA 94025, USA Howard Hughes Medical Institute, California Institute of Technology, Pasadena, CA 91125, USA
منابع مشابه
High-resolution analysis of Zn(2+) coordination in the alkaline phosphatase superfamily by EXAFS and x-ray crystallography.
Comparisons among evolutionarily related enzymes offer opportunities to reveal how structural differences produce different catalytic activities. Two structurally related enzymes, Escherichia coli alkaline phosphatase (AP) and Xanthomonas axonopodis nucleotide pyrophosphatase/phosphodiesterase (NPP), have nearly identical binuclear Zn(2+) catalytic centers but show tremendous differential speci...
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